Abstract
The structure-activity relationship of 2'-pyrrole, pyrazole and triazole substituted 2-(anilinomethyl)imidazolines as alpha(1) adrenergic agonists was investigated. The size and orientation of substituents, as well as the position of the heteroatoms, were found to have a profound effect on the potency and selectivity of the molecules. Potent alpha(1A) subtype selective agonists have been identified.
MeSH terms
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Adrenergic alpha-1 Receptor Agonists*
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Adrenergic alpha-Agonists / chemical synthesis*
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Adrenergic alpha-Agonists / pharmacology*
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Pyrazoles / chemical synthesis
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Pyrazoles / pharmacology
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Pyrroles / chemical synthesis
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Pyrroles / pharmacology
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Structure-Activity Relationship
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Triazoles / chemical synthesis
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Triazoles / pharmacology
Substances
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Adrenergic alpha-1 Receptor Agonists
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Adrenergic alpha-Agonists
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Pyrazoles
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Pyrroles
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Triazoles